Friday, January 17, 2014

Annual report of the Scientific Network on BSE-TSE EFSA, Question No EFSA-Q-2013-01004, approved on 11 December 2013

TECHNICAL REPORT

 

Annual report of the Scientific Network on BSE-TSE 20131

 

European Food Safety Authority2, 3

 

European Food Safety Authority (EFSA), Parma, Italy

 

ABSTRACT

 

The EFSA Scientific Network on bovine spongiform encephalopathies and other transmissible spongiform encephalopathies (BSE-TSE) held its 8th meeting on 8 and 9 October 2013 in Parma. The meeting served as an opportunity to exchange scientific information on BSE-TSE related issues among EU Member States, countries from the European Free Trade Association, EFSA, the European Commission and ad hoc participants. In this occasion, ad hoc representation included the World Animal Health Organisation (OIE), the EU Reference Laboratory for Proteins in Feed and the OIE-EU Reference Laboratory for animal TSEs. The issues discussed ranged from individual Member State cases studies (i.e. investigation of a potential BSE-like case in a goat in Poland) to worldwide issues of common interest in the field of BSE-TSE (i.e. update on activities of the OIE). Opportunities for topics that could be shared in the future in this Network were also discussed, and the Network Members and Observers expressed their interest to continue having yearly meetings.

 

© European Food Safety Authority, 2013

 

KEY WORDS

 

network, BSE, TSE, meeting

 

1 On request from EFSA, Question No EFSA-Q-2013-01004, approved on 11 December 2013.

 

2 Correspondence: biohaz@efsa.europa.eu

 

3 Acknowledgement: EFSA wishes to thank the BSE-TSE Network: Medical University of Vienna – Institute of Neurology (Austria), Veterinary and Agrochemical Research Centre (Belgium and Luxembourg), National Veterinary Service (Bulgaria), Ministry of Agriculture, Forestry and Water Management and Croatian Veterinary Institute (Croatia), Veterinary Services Cyprus (Cyprus), State Veterinary Institute Jihlava (Czech Republic), DTU Vet National Veterinary Institute, Technical University of Denmark (Denmark), Veterinary and Food Board, Animal Health, Welfare and Feedingstuffs Department (Estonia), Finnish Food Safety Authority-EVIRA (Finland), French Agency for Food, Environmental and Occupational Safety (France), Federal Institute for Risk Assessment (BfR) and Friedrich-Loeffler Institute (Germany), Ministry of Rural Development and Food (Greece), Ministry of Agriculture and Rural Development (Hungary), Department of Agriculture, Fisheries and Food (Ireland), Istituto Zooprofilattico e Sperimentale del Piemonte, Liguria e Val d’Aosta (Italy), Food and Veterinary Service (Latvia), State Food and Veterinary Service (Lithuania), Officer for Risk Assessment and Research, Netherlands Food and Consumer Products Safety Authority, Ministry of Economic Affairs (the Netherlands), National Veterinary Research Institute (Poland), Ministry of Agriculture (Portugal), National Sanitary Veterinary and Food Safety Authority (Romania), State Veterinary and Food Administration (Slovak Republic), Veterinary Administration (Slovenia), Ministry of Agriculture, Food and Environment Affairs (Spain), Swedish Zoonoses Centre National Veterinary Institute (Sweden), Food Standards Agency (United Kingdom) for the preparatory work on this output, and the Observers: National Veterinary Institute (Norway), Swiss Federal Veterinary Office (Switzerland), Ministry of Health (Former Yugoslav Republic of Macedonia), Ministry of Agriculture and Rural Affairs (Turkey), National Food Authority (Albania), University of Sarajevo (Bosnia-Herzegovina), Veterinary Directorate (Montenegro), Food and Veterinary Agency (Kosovo under UN Security Council Resolution 1244), Ministry of Agriculture, Forestry and Water Management (Serbia) and the EU Reference Laboratory for Proteins in Feed, the EU Reference Laboratory for animal TSEs and the World Animal Health Organisation for the support provided to this output.

 

Annual Report of EFSA’s BSE-TSE Network

 

EFSA supporting publication 2013:EN-532 2

 

SUMMARY

 

Developing networking and stronger co-operation with the Member States (MSs) and strengthening EFSA’s relationship with its institutional partners (EU and international) and stakeholders are among key recommendations formulated by EFSA’s Management Board. In accordance with EFSA’s strategy for cooperation and networking with MSs, the Scientific Network on BSE-TSE was launched in 2006. The BSE-TSE Network had its first meeting in 2006, and following this one meeting per year has been held.

 

The main overall goals of the BSE-TSE Network are to: improve dialogue among participants; build mutual understanding of risk assessment principles; enhance knowledge on and confidence in the scientific assessments carried out in the EU; and provide increased transparency in the current process among MSs and EFSA. In turn, it aims to raise the harmonisation level of the risk assessments developed in the EU.

 

The BSE-TSE Network is currently composed as follows: Network Members representing 27 EU MSs (Malta has not appointed a representative to this Network) and Network Observers representing countries from the European Free Trade Association (EFTA), EU Candidate Countries and Potential EU Candidate Countries. The European Commission Directorate-General of Health and Consumers and of Research are also Observers in the Network.

 

The eighth meeting of the Network was held on 8 and 9 October 2013 in Parma. In this occasion, representatives from the World Animal Health Organisation (OIE), the EU Reference Laboratory for Proteins in Feed (EURL-AP) and the EU Reference Laboratory for animal TSEs (EURL-TSE) were also present.

 

Beyond exchanging information on the activities in the BSE-TSE field carried out by Network Members, Observers, the European Commission and EFSA since the last meeting, several specific issues were discussed in the 2013 meeting. Key discussions included: past and present perspectives of BSE and TSE in Croatia, a scientific update on the potential for transmissibility of non-prion protein misfolding diseases, a case study on the characterisation of a potential BSE-like isolate from a goat in Poland and updates on BSE-TSE related activities form the OIE, the EURL-AP and the EURL-TSE.

 

Following discussion on potential further issues to be considered within the frame of the Network, it was decided by the Members and Observers of the Network to continue meeting once per year and to use the available electronic tools for discussion and data exchange if needed.

 

Annual Report of EFSA’s BSE-TSE Network

 

EFSA supporting publication 2013:EN-532 3

 

TABLE OF CONTENTS

 

Abstract .................................................................................................................................................... 1

 

Summary .................................................................................................................................................. 2

 

Table of contents ...................................................................................................................................... 3

 

Background as provided by EFSA ........................................................................................................... 4

 

Terms of reference as provided by EFSA ................................................................................................ 4

 

Activities .................................................................................................................................................. 6

 

1. Follow-up from annual meeting 2012 ............................................................................................. 6

 

2. Annual meeting 2013 ....................................................................................................................... 6

 

3. Planned Network activities for 2014 ............................................................................................... 8

 

Annual Report of EFSA’s BSE-TSE Network

 

EFSA supporting publication 2013:EN-532 4

 

BACKGROUND AS PROVIDED BY EFSA

 

The European Food Safety Authority (EFSA) is the keystone of European Union (EU) risk assessment regarding food and feed safety, animal health and welfare, nutrition, plant protection and plant health. In close collaboration with national authorities and in open consultation with its stakeholders, EFSA provides independent and transparent scientific advice and clear communication on existing and emerging risks associated with the food chain. On request from the European Commission, European Parliament or Member States (MSs) or on its own initiative1 EFSA provides scientific opinions on issues falling under its remit.

 

The Scientific Panel on Biological Hazards (BIOHAZ) provides independent scientific advice on biological hazards in relation to food safety and food-borne diseases. This covers: Food-borne zoonoses (animal diseases transmissible to humans); Transmissible spongiform encephalopathies (BSE-TSEs); Food microbiology; Food hygiene and associated waste management issues.

 

The Panel is one of EFSA’s key drivers on work on BSE and TSE. It carries out risk assessments in order to produce scientific opinions and advice for risk managers. The Panel’s risk assessment work is based on reviewing scientific information and data in order to evaluate the risks posed by a given issue. This helps to provide a sound foundation for European policies and legislation and supports risk managers in taking effective and timely decisions.

 

Developing networking and stronger co-operation with the MSs and strengthening EFSA’s relationship with its institutional partners (EU and international) and stakeholders are among the key recommendations formulated by EFSA’s Management Board. In accordance with EFSA’s strategy for cooperation and networking with MSs, the BSE-TSE Scientific Network was launched in 2006. The BSE/TSE Network had its first meeting in 2006 and following this, one meeting per year.

 

The seventh meeting of the Network was held on 10 and 11 October 2012. Members representing the MSs were appointed by the EU MSs themselves through the Advisory Forum and the EFSA Focal Points.

 

TERMS OF REFERENCE AS PROVIDED BY EFSA

 

The main overall goals of the Scientific Network on BSE-TSE are to: improve dialogue among participants; build mutual understanding of risk assessment principles; enhance knowledge on and confidence in the scientific assessments carried out in the EU; and to provide increased transparency in the current process among MSs and EFSA. In turn, it aims to raise the harmonisation level of the risk assessments developed in the EU.

 

The Network strengthens the scientific cooperation on BSE-TSE. It aims at anticipating and reducing the duplication of activities and hence avoiding divergence of opinion. The Network is a privileged environment to share data and methodologies facilitating harmonisation of assessment practices and assist in anticipating emerging risks in the EU.

 

The specific objectives of the Scientific Network on BSE-TSE are: Identifying common themes and areas for mutual collaboration. Identifying and avoiding duplication and divergence of opinion.

 

Annual Report of EFSA’s BSE-TSE Network

 

EFSA supporting publication 2013:EN-532 5

 

Identification of experts in specific areas and on special issues. Sharing of data availability and quality. Strengthening cooperation amongst risk assessors and managers. Exchanging information between EFSA, MSs and other stakeholders. Strengthening communication between EFSA-MSs and Risk Assessment-Risk Managers -Stakeholders. Focusing attention on and streamlining of common research needs. Identifying potential emerging risks when addressing current issues.

EFSA may entrust to the Network certain tasks, in particular preparatory work for scientific opinions, scientific and technical assistance, and collection of data.

 

The activities of the Network should be recorded in meeting minutes. In addition, an Annual Report summarising the activities will be produced.

 

Annual Report of EFSA’s BSE-TSE Network

 

EFSA supporting publication 2013:EN-532 6

 

ACTIVITIES

 

1. Follow-up from annual meeting 2012

 

At the 2012 BSE-TSE Network meeting, the Members and Observers of the Network highlighted several issues of interest. In particular, those issues have been addressed as follows:

 

1. Update the repository in EFSA’s Sciencenet (extranet information exchange platform) with information and presentations shared during all the Network meetings held. This has been updated and will automatically be updated after each Network meeting.

 

2. Analyse the questionnaire-based survey launched following the 2012 Network meeting on issues to be consider in 2013 Network meeting. This has been done and the agenda of the 2013 meeting reflected the issues addressed by Network Members and Observers.

 

2. Annual meeting 2013

 

The annual meeting was held on 8 and 9 October 2013 in Parma, and was attended by representatives from 22 European Union (EU) Member States (MS) (Austria, Belgium and Luxembourg, Bulgaria, Croatia, Cyprus, Czech Republic, Estonia, Finland, France, Greece, Hungary, Ireland, Italy, Latvia, The Netherlands, Poland, Romania, Slovak Republic, Slovenia, Spain and United Kingdom) and two EFTA countries (Norway and Switzerland). The European Commission (DG SANCO) was also present at the meeting. Further ad hoc attendees to this meeting included: Dr. Stuart MacDiarmid (World Organisation for Animal Health (OIE)), Dr. Gilbert Berben (EU-Reference Laboratory for Animal Proteins in Feedingstuffs (EURL-APF)) and Dr. Marion Simmons (EU Reference Laboratory and OIE Reference Laboratory for animal TSE (EURL-TSE)). Apologies were received from Network Members from Denmark, Germany, Lithuania, Portugal and Sweden. Malta has not appointed a representative to this EFSA Network. Further apologies were received from Network Observers from the EU Candidate and Potential Candidate countries who were not able to join in this occasion: Albania, Bosnia-Herzegovina, Former Yugoslav Republic of Macedonia, Kosovo under UN Security Council Resolution 1244, Montenegro, Serbia and Turkey.

 

The following are key issues that were discussed: Past and present BSE and TSE perspectives in Croatia.

 

Croatia was welcomed to the Network as a Member in this special occasion, following the adhesion of Croatia to the EU. The representative from Croatia presented historical and current experiences on the approach to BSE and TSE surveillance and controls. Historical preparedness activities aiming at building TSE-testing capacity and knowledge on TSE controls were carried out with the support of different countries in the past, in particular of the UK. BSE surveillance in cattle Croatia has not identified any positive case. Regarding other animal TSEs, a case of Atypical scrapie in sheep has been identified in 2013.

 

 

*** Update on activities of the OIE in the field of BSE and other animal TSEs

 

 

The representative from the World Organisation for Animal Health (OIE) presented the activities of this organisation related to BSE and scrapie. A short description of the current BSE epidemiological situation was presented. Considerations about Atypical BSE and other animal TSEs were discussed. The OIE representative highlighted that there were no particular activities ongoing at OIE level regarding the differentiation of BSE based on strain characterisation (i.e. Classical BSE, Atypical BSE). Recent modifications in the BSE chapter of the Terrestrial Animal Health Code regarding small countries were discussed.

 

 

*** Further, it was addressed that recently discussions have being held at OIE level on Chronic Wasting Disease of cervids.

 

 

Annual Report of EFSA’s BSE-TSE Network

 

EFSA supporting publication 2013:EN-532 7

 

Scientific update on the potential for transmissibility of non-prion protein misfolding diseases

 

The representative from Austria updated the participants on scientific issues related to the prion-like behaviour of altered proteins (‘prionoids’). The state of the art of experimental and epidemiological evidence on the potential for transmissibility of non-TSE protein misfolding diseases was presented. Experimental evidence shows that there are proteins (e.g. Abeta amyloid, tau, alpha-synuclein) that can behave in a similar way to the prion protein in terms of in-vivo propagation when experimentally inoculated animal models. There is no epidemiological evidence that human to human transmission has occurred in cases other than prion disorders. *** Still, it is acknowledged that the epidemiological investigation of the occurrence of this hypothetical phenomenon is not straight forward.

 

Case study on the typing of a potential BSE-like isolate from a goat in Poland

 

The representative from Poland described the scientific, technical and procedural aspects for the typing of TSE isolates from small ruminants. Firstly, the description of the bases for BSE and Scrapie strain-differentiation where presented with detail. This included not only the laboratory methods used but also an indication of the criteria that is applied for the characterisation of TSE isolates in animals. Secondly, available results of the typing of a potential BSE-like isolate from a goat in Poland were shown with detail. The EURL-TSE Strain Typing Expert Group (STEG) has preliminary classified the strain as not BSE, but BSE could not be fully excluded. Inoculation studies employing bioassay are ongoing in order to gain further information on the characteristics of this strain.

 

The EFSA Cattle TSE Monitoring Model (C-TSEMM)

 

The BIOHAZ Secretariat provided a live demonstration of the functioning of the EFSA C-TSEMM. The impact of different monitoring options in the overall performance of a monitoring programme was modelled employing some fictitious scenarios. The practical demonstration on the functioning of the model was found interesting by the meeting participants.

 

Update on activities of the EU-Reference Laboratory for Animal Proteins in Feedingstuffs (EURL-AP)

 

The representative from the EURL-AP provided an update on the recent EU regulatory instruments on certain aspects of testing for animal proteins in feedingstuffs. In particular, aspects of the proficiency testing done before the new legislation entered into force and specific methodological issues were presented. Further, experiences regarding limitations and findings during the first months of the implementation of the new regulation were discussed.

 

Update on activities of the EU-Reference Laboratory and OIE-Reference Laboratory for TSEs (EURL-TSE)

 

The representative form the EURL-TSE presented the activities of this EU and OIE reference laboratory. The roles of this reference laboratory when acting as EURL or as OIE-RL were presented. The tasks and challenges addresses by the laboratory are very wide. These include, among others: keeping of TSE-related reference materials (i.e. tissues), participation in the rapid screening of tests and approval of minor testing kit changes and follow up of unusual samples with the STEG. A brief description of the current epidemiological situation in the EU and worldwide was presented. The issue of Atypical BSE in the context of the current BSE epidemiological situation was discussed, emphasising the need for characterising isolates which is now required by regulations in the EU. Further issues beyond TSE diagnostics were also presented in detail, in particular experimental research on clinical aspects of different types of TSEs in sheep.

 

Annual Report of EFSA’s BSE-TSE Network

 

EFSA supporting publication 2013:EN-532 8

 

Update on the activities of the European Commission in the field of BSE-TSE

 

The representative from DG-SANCO provided a comprehensive review of recent (completed and ongoing) risk-management activities in different BSE-TSE related fields, which are coordinated by this Directorate General of the European Commission. A short update on activities in the Directorate General on Research and Innovation was also presented.

 

In addition to these discussion topics, the participants exchanged information on the risk assessment activities carried out since the last meeting at MS level and in EFSA. Details on some recent and planned TSE-related scientific publications were shared, in particular from Belgium and France.

 

The minutes of this meeting are published on the BSE Network section of the EFSA website4.

 

3. Planned Network activities for 2014

 

The period covering the current Mandate of the EFSA Scientific Network on BSE-TSE is expiring by the end of 2013.

 

The BIOHAZ Secretariat presented a draft reviewed mandate and terms of reference for the Network. This review followed from an analysis made in EFSA aiming at harmonising networking activities, which took into account recommendations received from Members of EFSA Networks through a questionnaire circulated in fall 2012 from the Secretariat of the EFSA Unit on Advisory Forum and Scientific Cooperation. The revised mandate and terms of reference were endorsed by the Members of this Network with some minor changes. Following this, a new mandate from EFSA will be sought in order to request the continuation of the EFSA Scientific Network on BSE-TSE.

 

A discussion followed on issues for future consideration in the frame of this Network. These included the following:

 

Include the possibility for inviting representatives from other countries or international organisations in order to have first-hand information on issues related to BSE and other animal TSEs.

 

Give consideration to issues related to animal by-products and find points of common interest that could be considered in this Network or in a parallel EFSA Network.

 

Encourage further active participation of members and observers in the agenda of the 2014 meeting. The Members and Observers of the Network found that exchanging knowledge in the context of the meeting of this EFSA Network was overall useful.

 

Those considerations made will be taken into account in the EFSA Secretariat when proposing and preparing future activities of this Network.

 

The Network Members and Observers expressed their interest in continuing having a yearly meeting. It was noted that it was the last meeting Prof. Budka was attending as the Network representative for Austria. The Network gratefully acknowledged his contribution throughout these years.

 

 


 

(last visited on 09/12/2013)

 

EFSA supporting publication 2013:EN-532

 

 


 

 

2014

 

 

>>> *** Further, it was addressed that recently discussions have being held at OIE level on Chronic Wasting Disease of cervids. <<<

 

 

2012

 

 

328. Agent causing chronic wasting disease (CWD)

 

Dr Ben Jebara summarised the situation of the agent causing chronic wasting disease (CWD) which was a transmissible spongiform encephalopathy (TSE), along with other spongiform diseases, such as scrapie and bovine spongiform encephalopathy. At the present time there was no scientific evidence that the infection was transmissible to domestic animals or to humans. Two countries reported the disease present in 2011: United States of America and Canada.

 

– 104 –

 

80 GS/FR – PARIS, May 2012

 

 


 

 

 

>>> *** Further, it was addressed that recently discussions have being held at OIE level on Chronic Wasting Disease of cervids. <<<

 

 

2002 Singeltary vs O.I.E. on CWD to human risk factor ;

 

 

Subject: Re: CWD AMERICA ???

 

Date: Fri, 12 Jul 2002 19:10:18 +0200

 

From: "INFORMATION DEPT"

 

Organization: O.I.E

 

To: "Terry S. Singeltary Sr."

 

References: <3d2f0169 .3="" wt.net=""> <012901c229b2 ad43bb90="" f00000a=""> 3D2F2358.5010700@wt.net

 

I agree with you Dr Terry. The OIE, namely the International Animal Health Code Commission is working on making proposals to Member Countries to change the OIE lists so to avoid some the problems mentioned in you e-mail. This will take at least two years before adoption by the International Committee. For BSE, countries asked the OIE to post information on BSE on the OIE web site.

 

Personally, I am interested in Chronic Wasting Disease and I follow what is distributed through ProMed. Delegates of OIE Member Countries can propose diseases to be added to the list.

 

Kind regards.

 

Karim Ben Jebara

 

 


 

 

----- Original Message -----

 

From: "Terry S. Singeltary Sr."

 

To: "INFORMATION DEPT"

 

Sent: Friday, July 12, 2002 8:43 PM

 

Subject: Re: CWD AMERICA ???

 

 

>>> *** Further, it was addressed that recently discussions have being held at OIE level on Chronic Wasting Disease of cervids. <<<

 

 

> hello Dr. Jebara,

 >

 > many thanks for your swift and kind reply.

 >

 > if i am not mistaken, it was the same email address.

 > it was 3 or 4 weeks ago i wrote, as it is, i don't

 > save 'sent' emails anymore, unless very important.

 >

 > my main concern (besides the fact that a potential TSE

 > has been in the USA cattle for some time, but the APHIS

 > do not test to find), is that the CWD could very well be

 > transmitting to humans, and i just did not see to much

 > posted about it on OIE site.

 >

 > > Coming back to your question, Chronic Wasting Disease is not an OIE

 >

 > > listed disease. Please see OIE disease lists at

 >


 >

 > why is this TSE (CWD) not listed and followed as with BSE ?

 >

 > Article 1.1.3.2.

 > 1. Countries shall make available to other countries, through the

 > OIE, whatever information is necessary to minimise the spread of

 > important animal diseases and to assist in achieving better worldwide

 > control of these diseases.

 >


 >

 > The USA CWD is an important animal disease.

 >

 > why is it not followed?

 >

 > > The decision to add or delete a disease from the OIE lists, come

 >

 > > through proposals made by Member Countries and it has to be adopted by

 >

 > > the International Committee.

 >

 > i _urgently_ suggest a proposal to the OIE to follow this disease very

 > closely, and to propose _more_ testing in the USA for TSEs in the USA

 > cattle...

 >

 > kindest regards,

 > terry

 >

 > INFORMATION DEPT wrote:

 >

 > > Dear Sir,

 > >

 > > This is the first time that I receive your e-mail. To whom have you written

 > > in the OIE or to which address?

 > >

 > > Coming back to your question, Chronic Wasting Disease is not an OIE listed

 > > disease. Please see OIE disease lists at


 > >

 > > Countries should report to the OIE any disease even is not listed in the

 > > OIE's lists in some conditions (example: an exceptional epidemiological

 > > event). Please read Chapter 1.1.3 of the International animal health code to

 > > have more information on disease notification and epidemiological

 > > information agreed by OIE Member Countries at :


 > >

 > > The decision to add or delete a disease from the OIE lists, come through

 > > proposals made by Member Countries and it has to be adopted by the

 > > International Committee.

 > >

 > > Hope that I answered to your question.

 > >

 > > Best regards.

 > >

 > > Dr Karim Ben Jebara

 > > Head

 > > Animal Health Information Department

 > > OIE

 > >

 > >

 > >

 > > ----- Original Message -----

 > > From: "Terry S. Singeltary Sr."

 > > To:

 > > Sent: Friday, July 12, 2002 6:18 PM

 > > Subject: CWD AMERICA ???

 > >

 > >

 > >

 > >>I WROTE TO OIE RECENTLY ASKING 'WHY OIE DOES NOT FOLLOW CWD IN

 > >>AMERICA' ? with no reply ? i am still seeking an answer ?

 > >>

 > >>many thanks,

 > >>and kind regards,

 > >>terry

=====================

 

 


 

 

----- Original Message -----

 

From: "Terry S. Singeltary Sr."

 

To: "INFORMATION DEPT"

 

Sent: Friday, July 12, 2002 8:43 PM

 

Subject: Re: CWD AMERICA ???

 

hello Dr. Jebara,

 

many thanks for your swift and kind reply.

 

if i am not mistaken, it was the same email address. it was 3 or 4 weeks ago i wrote, as it is, i don't save 'sent' emails anymore, unless very important.

 

my main concern (besides the fact that a potential TSE has been in the USA cattle for some time, but the APHIS do not test to find), is that the CWD could very well be transmitting to humans, and i just did not see to much posted about it on OIE site.

 

Coming back to your question, Chronic Wasting Disease is not an OIE

 

listed disease. Please see OIE disease lists at

 

 


 

 

why is this TSE (CWD) not listed and followed as with BSE ?'

 

 

Article 1.1.3.2. 1. Countries shall make available to other countries, through the OIE, whatever information is necessary to minimise the spread of important animal diseases and to assist in achieving better worldwide control of these diseases.

 


 

 

The USA CWD is an important animal disease.

 

why is it not followed?

 

The decision to add or delete a disease from the OIE lists, come through proposals made by Member Countries and it has to be adopted by the International Committee.

 

i _urgently_ suggest a proposal to the OIE to follow this disease very closely, and to propose _more_ testing in the USA for TSEs in the USA cattle...

 

 

kindest regards, terry

 

END

 

 


 

 

 

>>> *** Further, it was addressed that recently discussions have being held at OIE level on Chronic Wasting Disease of cervids. <<<

 

 

*** PRICE OF CWD TSE PRION POKER GOES UP 2014 ***

 

 

Transmissible Spongiform Encephalopathy TSE PRION update January 2, 2014

 

 

*** chronic wasting disease, there was no absolute barrier to conversion of the human prion protein.

 

 

*** Furthermore, the form of human PrPres produced in this in vitro assay when seeded with CWD, resembles that found in the most common human prion disease, namely sCJD of the MM1 subtype.

 

 

Wednesday, January 01, 2014

 

Molecular Barriers to Zoonotic Transmission of Prions

 

 

*** chronic wasting disease, there was no absolute barrier to conversion of the human prion protein.

 

 

*** Furthermore, the form of human PrPres produced in this in vitro assay when seeded with CWD, resembles that found in the most common human prion disease, namely sCJD of the MM1 subtype.

 

 


 

 


 

 

*** The potential impact of prion diseases on human health was greatly magnified by the recognition that interspecies transfer of BSE to humans by beef ingestion resulted in vCJD. While changes in animal feed constituents and slaughter practices appear to have curtailed vCJD, there is concern that CWD of free-ranging deer and elk in the U.S. might also cross the species barrier. Thus, consuming venison could be a source of human prion disease. Whether BSE and CWD represent interspecies scrapie transfer or are newly arisen prion diseases is unknown. Therefore, the possibility of transmission of prion disease through other food animals cannot be ruled out. There is evidence that vCJD can be transmitted through blood transfusion. There is likely a pool of unknown size of asymptomatic individuals infected with vCJD, and there may be asymptomatic individuals infected with the CWD equivalent. These circumstances represent a potential threat to blood, blood products, and plasma supplies.

 


 

 

Friday, November 22, 2013

 

*** Wasting disease is threat to the entire UK deer population CWD TSE prion Singeltary submission

 


 

 

Wednesday, September 04, 2013

 

*** cwd - cervid captive livestock escapes, loose and on the run in the wild

 


 

 

Sunday, September 01, 2013

 

hunting over gut piles and CWD TSE prion disease

 


 

 

Wednesday, January 01, 2014

 

APHIS-2006-0118-0100 Chronic Wasting Disease Herd Certification Program and Interstate Movement of Farmed or Captive Deer, Elk, and Moose

 


 

 

Sunday, December 15, 2013

 

*** FDA PART 589 -- SUBSTANCES PROHIBITED FROM USE IN ANIMAL FOOD OR FEED VIOLATIONS OFFICIAL ACTION INDICATED OAI UPDATE DECEMBER 2013 UPDATE

 


 

 

Saturday, December 21, 2013

 

**** Complementary studies detecting classical bovine spongiform encephalopathy infectivity in jejunum, ileum and ileocaecal junction in incubating cattle ****

 


 

 

Wednesday, December 4, 2013

 

*** Bovine Spongiform Encephalopathy; Importation of Bovines and Bovine Products; Final Rule Federal Register / Vol. 78 , No. 233 / Wednesday, December 4, 2013

 


 

 

Saturday, November 2, 2013

 

*** APHIS Finalizes Bovine Import Regulations in Line with International Animal Health Standards while enhancing the spread of BSE TSE prion mad cow type disease around the Globe

 


 

 


 

 

Thursday, December 05, 2013

 

National Scrapie Eradication Program October 2013 Monthly Report Fiscal Year 2014 TSE PRION REPORT

 


 

 

Tuesday, October 29, 2013

 

VARIANT CJD PRESENTS DIFFERENTLY IN OLDER PATIENTS

 


 

 

Wednesday, October 09, 2013

 

*** WHY THE UKBSEnvCJD ONLY THEORY IS SO POPULAR IN IT'S FALLACY, £41,078,281 in compensation REVISED

 


 

 

Thursday, October 10, 2013

 

CJD REPORT 1994 increased risk for consumption of veal and venison and lamb

 


 

 

Friday, August 16, 2013

 

*** Creutzfeldt-Jakob disease (CJD) biannual update August 2013 U.K. and Contaminated blood products induce a highly atypical prion disease devoid of PrPres in primates

 


 

 

WHAT about the sporadic CJD TSE proteins ?

 

WE now know that some cases of sporadic CJD are linked to atypical BSE and atypical Scrapie, so why are not MORE concerned about the sporadic CJD, and all it’s sub-types $$$

 

Creutzfeldt-Jakob Disease CJD cases rising North America updated report August 2013

 

*** Creutzfeldt-Jakob Disease CJD cases rising North America with Canada seeing an extreme increase of 48% between 2008 and 2010 ***

 


 

 

Sunday, October 13, 2013

 

*** CJD TSE Prion Disease Cases in Texas by Year, 2003-2012

 


 

 

 

>>Our results provide compelling evidence that α-synuclein aggregates formed in the brains of MSA patients are transmissible and, as such, are prions.<<<

 

 

 

Tuesday, November 26, 2013

 

Transmission of multiple system atrophy prions to transgenic mice

 


 

 

Wednesday, May 16, 2012

 

Alzheimer’s disease and Transmissible Spongiform Encephalopathy prion disease, Iatrogenic, what if ?

 

Proposal ID: 29403

 


 

 

Tuesday, July 17, 2012

 

*** O.I.E. BSE, CWD, SCRAPIE, TSE PRION DISEASE Final Report of the 80th General Session, 20 - 25 May 2012

 


 

 

Friday, January 17, 2014

 

Taiwan Opening to Canadian beef conditional: Health Ministry BSE CJD UPDATE

 


 

 

IN A NUT SHELL ;

 

(Adopted by the International Committee of the OIE on 23 May 2006)

 

11. Information published by the OIE is derived from appropriate declarations made by the official Veterinary Services of Member Countries. The OIE is not responsible for inaccurate publication of country disease status based on inaccurate information or changes in epidemiological status or other significant events that were not promptly reported to the Central Bureau,

 


 

 

 


 

 

 

layperson

 

 

mom dod 12/14/97 confirmed hvCJD, just made a promise to mom, never forget, never let them forget. ...

 

 

 

Thursday, January 2, 2014

 

*** CWD TSE Prion in cervids to hTGmice, Heidenhain Variant Creutzfeldt-Jacob Disease MM1 genotype, and iatrogenic CJD ??? ***

 


 

 

 

 

kind regards,

 

Terry S. Singeltary Sr.

P.O. Box 42

Bacliff, Texas USA 77518


 

Wednesday, July 6, 2011

Mad cow disease: EU must maintain strict controls, says Parliament

Mad cow disease: EU must maintain strict controls, says Parliament

Food safety - 06-07-2011 - 15:00 Plenary sessions

The sharp fall in bovine spongiform encephalopathy (BSE) cases in the EU must not lead to a slackening of surveillance, say MEPs in a resolution passed on Wednesday. Any change to BSE safety rules must maintain high animal and public health standards, but the ban on feeding animal protein to non-ruminants, such as pigs, could gradually be lifted if further safeguards are put in place, they add.

Changes to current EU laws, which the Commission is about to review, could include new rules on removing specific risk materials from animal feed, a gradual relaxation of the animal protein feed ban, changes to cohort culling policy and a higher age limit for BSE testing, says the non-legislative resolution, drafted by Dagmar Roth Behrendt (S&D, DE).

MEPs reject a Commission proposal to reduce EU funding on research into transmissible spongiform encephalopathies (TSEs), including BSE.

Strict conditions for any feed ban review

The Commission's TSE Roadmap 2 moots a possible gradual lifting of the prohibition on the feeding of processed animal proteins to non-ruminants. Given the EU's "protein deficit", MEPs back this idea, subject to strict conditions and safeguards. These include stipulating that the processed animal proteins must come from species not linked to TSE, and may be fed only to non-herbivores. Prohibitions on cannibalism must remain and only processed animal proteins fit for human consumption should be used, MEPs add.

Food and feed contamination

Commenting on wider food and feed safety, MEPs express concern about recent contamination cases, e.g. with dioxin, and call on EU Member States to enforce existing rules and strengthen them, if necessary.

TSEs

TSEs cause degeneration of brain tissue leading to death in man and animals. They include Creutzfeldt-Jakob disease and Kuru in humans, bovine spongiform encephalopathy in cattle and scrapie in sheep and goats.

Procedure: Non-legislative resolution

REF. : 20110705IPR23380

http://www.europarl.europa.eu/en/pressroom/content/20110705IPR23380/html/Mad-cow-disease-EU-must-maintain-strict-controls-says-Parliament


Saturday, November 6, 2010

TAFS1 Position Paper on Position Paper on Relaxation of the Feed Ban in the EU Berne, 2010 TAFS

INTERNATIONAL FORUM FOR TRANSMISSIBLE ANIMAL DISEASES AND FOOD SAFETY a non-profit Swiss Foundation

http://madcowfeed.blogspot.com/2010/11/tafs1-position-paper-on-position-paper.html


Archive Number 20101206.4364 Published Date 06-DEC-2010 Subject PRO/AH/EDR> Prion disease update 2010 (11)

PRION DISEASE UPDATE 2010 (11)

http://www.promedmail.org/pls/apex/f?p=2400:1001:5492868805159684::NO::F2400_P1001_BACK_PAGE,F2400_P1001_PUB_MAIL_ID:1000,86129



Wednesday, July 06, 2011

Swine Are Susceptible to Chronic Wasting Disease by Intracerebral Inoculation


http://chronic-wasting-disease.blogspot.com/2011/07/swine-are-susceptible-to-chronic.html




Tuesday, July 5, 2011

Risk Assessment of BSE Introduction in the Russian Federation in Connection with Importation of Cattle from the European Union in 2005–2010

http://efsaopinionbseanimalprotein.blogspot.com/2011/07/risk-assessment-of-bse-introduction-in.html



TSS

Tuesday, July 5, 2011

Risk Assessment of BSE Introduction in the Russian Federation in Connection with Importation of Cattle from the European Union in 2005–2010

Risk.40: Risk Assessment of BSE Introduction in the Russian Federation in Connection with Importation of Cattle from the European Union in 2005–2010

Sergey Rybakov† and Alexander Yegorov

FGI Federal Centre for Animal Health; Vladimir, Russia†Presenting author; Email: s.s.rybakov@mail.ru

The study is aimed at quantitative assessment of risk of BSE introduction from the EU countries into Russia with breeding animals imported during 2005–2010.

Within 2005–2010 importation of cattle born in 2003–2008 from the EU into Russia totally amounted to 363,000 animals. According to the data published in the EU reports, during 2003–2008 the BSE prevalence in the EU countries reduced from 125 cases per million bovine animals above 24 months of age in 2003 to 12 cases in 2008. If the imported subpopulation had proportionally represented all age-groups of cattle from EU25 countries, according to the calculation 19.4 animals in BSE incubation period should have been imported from 2005 until 2010.

The main suppliers of breeding cattle into Russia are the following EU countries: Austria, Denmark, France, Finland, Germany, Hungary and The Netherlands. Since 2007 import from these countries has amounted to 67.5% of the total import. The major suppliers—not the EU member states—are Canada (12.2%), Australia (12.1%) and the US (5.8%). As for the UK, Poland and Portugal, i.e. countries having the highest BSE incidence, currently export of live cattle from there is banned. Calculations demonstrated that limitation of live cattle importation from the countries with high BSE incidence allows to reduce the risk of BSE introduction into Russia in 14.5 times.

Risk assessment in relation to BSE in animals born after 2003 was performed by EFSA in 2009. The EFSA results demonstrated that estimated number of BSE cases in EU17 countries amounted totally to 32 cases within 2003–2008 and the highest 95% confidence limit constituted 65 cases. As for seven above mentioned live cattle importing countries the estimated number of BSE cases within 2003-2008 averaged to 1.8 and upper 95% confidence limit was 3.6.

Given that share of cattle annually exported from these seven countries into Russia averages to 0.293%, according to calculations, within 2005-2010 the mean probability of importation of an animal in which BSE can be detected amounts to 0.0064 and the highest probability amounts to 0.0129.

Results of the risk assessment of BSE introduction with cattle imported into Russia from the above mentioned seven countries within 2005-2010 demonstrate that the risk of BSE introduction amounts to 0.01 case in six years and implementation of measures recommended in the OIE Code is sufficient for BSE risk reduction. More detailed information will be provided in the poster.

http://www.prion2011.ca/files/PRION_2011_-_Posters_(May_5-11).pdf




Greetings,


IN my opinion, from the following risk factors i will post below, and the fact that the OIE and the USDA systematically did away with the BSE GBR system for the BSE MRR system, for the legal trading all strains of TSE globally, and the ramifications there from (BSE MRR), MY confidence level of any TSE regulatory risk assessment is 0...that is ZERO CONFIDENCE LEVEL IN ANY REGARDS TO THE TSE PRION DISEASES AKA MAD COW DISEASE. The BSE MRR regulations were set up to fail, and make legal the trading of all strains of TSE prion disease globally. the consumers were hung out to dry around the globe, and the ramifications there from will be long and costly thanks to the OIE and the USDA et al. ...TSS



================================



DRAFT OPINION OF THE SSC ON THE GEOGRAPHICAL BSE-RISK (GBR) AND ITS EVOLUTION OVER TIME IN THE EUROPEAN UNION MEMBER STATES

The question: The SSC has been requested to provide an up-to-date assessment of the geographical BSE risk of the Member States of the European Union, taking account of the latest information and data that are available, including those provided by the Member States in their application for a BSE-Status categorisation.

Background: Regulation EC/999/2001 addresses the risk management measures needed for transmissible animal spongiform encephalopathies. It links these measures to the BSE-Status of the countries concerned, including Member States. It is therefore necessary that all Member States and all other countries which desire to trade certain products with the EU are categorised with regard to their BSE-status. The regulation foresees 5 categories and specifies the conditions for each of these. One condition is that a risk assessment is carried out, forming the basis for the subsequent status categorisation. The Commission has decided that for the purpose of the Regulation the SSC’s GBR assessment provides for the necessary risk assessment. Countries may, however, provide their own risk assessment in which case the SSC will be asked to provide a scientific opinion on the validity of it.

Opinion Introduction: In the year 20001 the SSC assessed, with the exception of Greece which did not provide the needed data, the GBR of all the Member States of the European Union. It applied an innovative methodology based on an integrated evaluation of "external challenge" (i.e. imports2 of live animals and MBM from countries with notified cases of BSE) and of "stability" (i.e. ability to avoid recycling of BSE-infectivity). This method was also described in the GBR-opinion of the SSC of July 2000. Two countries (UK and PT) were classified as GBR IV; nine countries (BE, DK, FR, DE, IRL, IT, LUX, NL and SP) were classified as GBR III and three (AT, FINL and SW) as GBR II. Since then, BSE-cases have been notified in DE, IT and SP, confirming the GBR assessment, but also in AT, SF and GR. The finding of BSE in AT and SF lead the SSC, among other considerations, to update its GBR-assessment methodology. This update was adopted by the SSC in January 2002. It foresees that "external challenge" results not only from live animals and MBM imports from countries with notified

http://ec.europa.eu/food/fs/sc/ssc/out249_en.pdf



Report on the assessment of the Geographical BSE-risk of AUSTRIA July 2000

5. CONCLUSION ON THE GEOGRAPHICAL BSE-RISK 5.1. THE CURRENT GBR • The current geographical BSE-risk (GBR) level is II: it is unlikely that domestic cattle are either clinically or pre-clinically infected with the BSEagent, however, it cannot be excluded.

http://ec.europa.eu/food/fs/sc/ssc/out115_en.pdf




Report on the assessment of the Geographical BSE-risk of DENMARK July 2000

5. CONCLUSION ON THE GEOGRAPHICAL BSE-RISK

5.1 The current GBR The current geographic BSE-risk (GBR) level is III, i.e. BSE is confirmed at a lower level.

On 28 February 2000 one case of BSE was diagnosed.

This case was detected by a passive surveillance system that is not able to identify all cases.

http://ec.europa.eu/food/fs/sc/ssc/out117_en.pdf




Report on the assessment of the Geographical BSE-risk of FRANCE July 2000

5. CONCLUSION ON THE GEOGRAPHICAL BSE-RISK

5.1. The current GBR The current geographic BSE risk (GBR) of France is level III, i.e. BSE is confirmed in domestic cattle at a lower level.

The observed incidence of clinical cases over the last 12 months (1st February 1999 to 29 February 2000) is 2.9 per 1 million adult cattle.

This figure is generated by a passive surveillance system not able to discover all clinical BSEcases.

http://ec.europa.eu/food/fs/sc/ssc/out119_en.pdf




Report on the assessment of the Geographical BSE-risk of FINLAND July 2000

5 THE GEOGRAPHICAL BSE-RISK

5.1 The current GBR as function of the past stability and challenge The current geographical BSE-risk (GBR) level is II, i.e. it is unlikely but cannot be excluded that cattle is infected (clinical or pre-clinical) with the BSE agent.

Note: This assessment is based on the assumption that the MBM imports from the Netherlands or other European Countries in 1988/89 did not pose a very high challenge. Given the uncertainty of this assumption that results from the fact that thousands of tonnes of MBM were exported at that time from the UK to other European countries, inter alia to the Netherlands, and from the practical impossibility to monitor the trade flows of that MBM, this assumption might be wrong. In that case Finland would have been exposed to a very high external challenge at a moment when the system was unstable. It therefore would have to be seen as GBR-level III.

http://ec.europa.eu/food/fs/sc/ssc/out118_en.pdf




Report on the assessment of the Geographical BSE-risk of GERMANY July 2000

5. CONCLUSION ON THE GEOGRAPHICAL BSE-RISK

5.1 The current GBR The current geographical BSE-risk (GBR) level is III, i.e. it is likely that domestic cattle are (clinically or pre-clinically) infected with the BSE-agent but it is not confirmed.

The current surveillance system is depending on notification of suspects, i.e. it is passive, and therefore not able to detect all clinical BSE cases. The probability that BSE is confirmed in Germany within the next years is significant, in particular if active surveillance would improve the performance of the surveillance system.

http://ec.europa.eu/food/fs/sc/ssc/out120_en.pdf




Report on the assessment of the Geographical BSE-risk of Hungary March 2001

5. CONCLUSION ON THE GEOGRAPHICAL BSE-RISK

5.1 The current GBR as function of the past stability and challenge

The current geographical BSE-risk (GBR) level is III, i.e. it is likely but not confirmed that domestic cattle are (clinically or pre-clinically) infected with the BSE-agent.

http://ec.europa.eu/food/fs/sc/ssc/out196_en.pdf




Report on the assessment of the Geographical BSE-risk of THE NETHERLANDS July 2000

5. THE GEOGRAPHICAL BSE-RISK

5.1 The current GBR The current geographical BSE-risk (GBR) level is III, i.e. BSE is confirmed in domestic cattle at a lower level.

However, the observed incidence of clinical cases over the period 1/3/99 to 29/2/2000 was 0.5 per 1 Million adult cattle. This figure is generated by a passive surveillance system that is not able to identify all clinical cases.

http://ec.europa.eu/food/fs/sc/ssc/out124_en.pdf




FINAL REPORT OF AN AUDIT CARRIED OUT IN ROMANIA FROM 07 TO 18 FEBRUARY 2011 IN ORDER TO EVALUATE MEASURES CONCERNING BOVINE SPONGIFORM ENCEPHALOPATHY (BSE)

Executive Summary This report describes the outcome of an audit carried out by the Food and Veterinary Office (FVO) in Romania, from 7 to 18 February 2011.

The objective of the audit was to evaluate the implementation of requirements concerning Bovine Spongiform Encephalopathy (BSE), as laid down in Regulation (EC) No 999/2001.

In terms of scope, the audit concentrated on BSE epidemio-surveillance in bovines, measures taken after suspicion/confirmation of BSE, removal and handling of specified risk material (SRM) from bovines, and the prohibition of feeding products of animal origin to farmed animals and exceptions applicable to this ban. The evaluation included measures taken in response to the recommendations made in a previous FVO audit regarding the afore-mentioned issues.

Overall, the report concludes that very limited progress has been made in order to address the recommendations of the previous FVO audit. In particular, BSE active epidemio-surveillance and compliance with SRM rules are significantly affected by the lack of arrangements for the collection of brain samples and SRM at backyard farms, where the majority of the bovine population is kept. There are also weaknesses concerning feed-ban controls.

The report makes a number of recommendations addressed to the Romanian competent authorities, aimed at rectifying the shortcomings identified and further enhancing the implementing and control measures in place.



http://ec.europa.eu/food/fvo/act_getPDF.cfm?PDF_ID=8947




http://ec.europa.eu/food/fvo/act_getPDFannx.cfm?ANX_ID=6451




http://ec.europa.eu/food/fvo/ap/ap_ro_2011-8950.pdf




Scientific Report of the European Food Safety Authority on the Assessment of the Geographical BSE-Risk (GBR) of AUSTRALIA.

Question N°

EFSA-Q-2003-083 Adopted July 2004

SUMMARY OF SCIENTIFIC REPORT

The European Food Safety Authority and its Scientific Expert Working Group on the Assessment of the Geographical Bovine Spongiform Encephalopathy (BSE) Risk (GBR) were asked by the European Commission (EC) to provide an up-to-date scientific report on the GBR in Australia, i.e. the likelihood of the presence of one or more cattle being infected with BSE, pre-clinically as well as clinically, in Australia. This scientific report addresses the GBR of Australia as assessed in 2004 based on data covering the period 1980-2003. In the case of Australia, an extremely or very unstable system was exposed to a very low or negligible challenge through the import of cattle. Under these conditions, it is highly unlikely that any internal challenge occurred. Given the negligible level of external challenge through meat and bone meal (MBM), it is highly unlikely that any internal challenge occurred. The risk that BSE-infected cattle entered processing in Australia and were, at least partly, rendered for feed, due to imported cattle from BSE-risk countries has been very low to negligible throughout the considered period. Some imports of cattle in the early 80s from the UK and from the mid-80s onwards from USA, Canada and European countries increased the risk of BSE infectivity entering the feed chain. However, the probability that BSE contaminated material entered processing is seen as being very low. EFSA concludes that the current GBR Australia level is I, i.e., it is highly unlikely that domestic cattle are (clinically or pre-clinically) infected with the BSE-agent. As long as the possibility of cross-contamination exists and there are no serious changes in rendering, the system will continue to be very unstable. Thus, the possibility of cattle being (pre-clinically or clinically) infected with the BSE-agent will remain at a low level.

Key words: BSE, geographical risk assessment, GBR, Australia, third countries

http://www.efsa.europa.eu/it/scdocs/doc/s6r.pdf



Scientific Report of the European Food Safety Authority on the Assessment of the Geographical BSE-Risk (GBR) of CANADA

Question N° EFSA-Q-2003-083

Adopted July 2004 SUMMARY OF SCIENTIFIC REPORT

The European Food Safety Authority and its Scientific Expert Working Group on the Assessment of the Geographical Bovine Spongiform Encephalopathy (BSE) Risk (GBR) were asked to provide an up-to-date scientific report on the GBR in Canada, i.e. the likelihood of the presence of one or more cattle being infected with BSE, pre-clinically as well as clinically, in Canada. This scientific report addresses the GBR of Canada as assessed in 2004 based on data covering the period 1980-2003. The BSE agent was probably imported into the country middle of the eighties and could have reached domestic cattle in the early nineties. These cattle imported in the mid eighties could have been rendered in the late eighties and therefore led to an internal challenge in the early 90s. It is possible that imported meat and bone meal (MBM) into Canada reached domestic cattle and led to an internal challenge in the early 90s. A certain risk that BSE-infected cattle entered processing in Canada, and were at least partly rendered for feed, occurred in the early 1990s when cattle imported from UK in the mid 80s could have been slaughtered. This risk continued to exist, and grew significantly in the mid 90’s when domestic cattle, infected by imported MBM, reached processing. Given the low stability of the system, the risk increased over the years with continued imports of cattle and MBM from BSE risk countries. EFSA concludes that the current GBR level of Canada is III, i.e. it is confirmed at a lower level that domestic cattle are (clinically or pre-clinically) infected with the BSE-agent. As long as the system remains unstable, it is expected that the GBR continues to grow, even if no additional external challenges occur.

Key words: BSE, geographical risk assessment, GBR, Canada, third countries

http://www.efsa.europa.eu/en/scdocs/doc/s2r.pdf



Thursday, February 10, 2011

TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHY REPORT UPDATE CANADA FEBRUARY 2011 and how to hide mad cow disease in Canada Current as of: 2011-01-31

http://madcowtesting.blogspot.com/2011/02/transmissible-spongiform-encephalopathy.html




Friday, March 4, 2011

Alberta dairy cow found with mad cow disease

http://transmissiblespongiformencephalopathy.blogspot.com/2011/03/alberta-dairy-cow-found-with-mad-cow.html




Wednesday, August 11, 2010

REPORT ON THE INVESTIGATION OF THE SIXTEENTH CASE OF BOVINE SPONGIFORM ENCEPHALOPATHY (BSE) IN CANADA

http://bse-atypical.blogspot.com/2010/08/report-on-investigation-of-sixteenth.html




Thursday, August 19, 2010

REPORT ON THE INVESTIGATION OF THE SEVENTEENTH CASE OF BOVINE SPONGIFORM ENCEPHALOPATHY (BSE) IN CANADA

http://bseusa.blogspot.com/2010/08/report-on-investigation-of-seventeenth.html




Scientific Report of the European Food Safety Authority on the Assessment of the Geographical BSE-Risk (GBR) of United States of America (USA)

Question N° EFSA-Q-2003-083

Adopted July 2004

Summary of scientific report The European Food Safety Authority and its Scientific Expert Working Group on the Assessment of the Geographical Bovine Spongiform Encephalopathy (BSE) Risk (GBR) were asked by the European Commission (EC) to provide an up-to-date scientific report on the GBR in the United States of America, i.e. the likelihood of the presence of one or more cattle being infected with BSE, pre-clinically as well as clinically, in USA. This scientific report addresses the GBR of USA as assessed in 2004 based on data covering the period 1980-2003. The BSE agent was probably imported into USA and could have reached domestic cattle in the middle of the eighties. These cattle imported in the mid eighties could have been rendered in the late eighties and therefore led to an internal challenge in the early nineties. It is possible that imported meat and bone meal (MBM) into the USA reached domestic cattle and leads to an internal challenge in the early nineties. A processing risk developed in the late 80s/early 90s when cattle imports from BSE risk countries were slaughtered or died and were processed (partly) into feed, together with some imports of MBM. This risk continued to exist, and grew significantly in the mid 90’s when domestic cattle, infected by imported MBM, reached processing. Given the low stability of the system, the risk increased over the years with continued imports of cattle and MBM from BSE risk countries. EFSA concludes that the current GBR level of USA is III, i.e. it is likely but not confirmed that domestic cattle are (clinically or pre-clinically) infected with the BSE-agent. As long as there are no significant changes in rendering or feeding, the stability remains extremely/very unstable. Thus, the probability of cattle to be (pre-clinically or clinically) infected with the BSE-agent persistently increases.

Key words: BSE, geographical risk assessment, GBR, USA, third countries

http://www.efsa.europa.eu/en/scdocs/doc/s3r.pdf




Annex to the EFSA Scientific Report (2004) 3, 1-17 on the Assessment of the Geographical BSE Risk of USA - 1 - European Food Safety Authority Scientific Expert Working Group on GBR Working Group Report on the Assessment of the Geographical BSE-Risk (GBR) of UNITED STATES OF AMERICA 2004

Annex to the EFSA Scientific Report (2004) 3, 1-17 on the Assessment of the Geographical BSE Risk of USA - 7 - 2.3

Overall assessment of the external challenge

The level of the external challenge that has to be met by the BSE/cattle system is estimated according to the guidance given by the SSC in its final opinion on the GBR of July 2000 (as updated in January 2002). Live cattle imports: In total the country imported 2038 (other sources) or 1128 (CD) live cattle from BSE risk countries other than Canada, of which 327 (other sources) or 323 (CD) came from the UK. From Canada the imports were >500,000 animals per year. The numbers shown in table 1 are the raw import figures and are not reflecting the adjusted imports for the assessment of the external challenge. Broken down to 5 year periods the resulting external challenge is as given in table 3. This assessment takes into account the different aspects discussed above that allow to assume that certain imported cattle did not enter the domestic BSE-cattle system, i.e. were not rendered into feed. In the case of the USA, all the animals for which tracing information showed that they were not rendered were excluded from the external challenge.

MBM imports:

In total the country imported 689 tons MBM (CD) or 2,230 tons MBM (other sources) from BSE risk countries other than Canada, of which 5 tons (CD) or 101 tons (other sources) were exported from the UK (UK export data). From Canada, the imports were about 30 000 tons per year. The numbers shown in table 2 are the raw import figures and are not reflecting the adjusted imports for the assessment of the external challenge. Broken down to 5 year periods the resulting external challenge is as given in table 3. This assessment takes into account the different aspects discussed above that allow to assume that certain imported MBM did not enter the domestic BSE/cattle system or did not represent an external challenge for other reasons. As it was illegal to export mammalian MBM from UK since 27/03/1996, exports indicated after that date should only have included non-mammalian MBM. In the case of the USA imported MBM from UK in 1989 and between 1997 and 1999 was not taken into account.

Feeding Use of MBM in cattle feed

• Until 1997 ruminant MBM (RMBM) could legally be included in cattle feed and was indeed commonly fed to cattle of different age and type. Prior to the feed ban the US authorities estimated that 10% of all MBM would deliberately have been fed to cattle. Feed bans

• A ban to feed (several types of) MMBM to ruminants was put in place in August 1997. Derogation from the ban was granted for pure porcine and equine protein (MBM) coming from designated (single species) rendering plants. This MMBM might still be fed to cattle. Therefore this feed ban is a ruminant to ruminant ban.

• It is planned to prohibit the use of all mammalian and poultry protein in ruminant feed and prohibiting materials from non-ambulatory disabled cattle and dead stock from use in all animal feed.

Conclusion on the ability to avoid recycling

• Before 1997, US system would not have been able to avoid recycling of the BSEagent to any measurable extent. If the BSE-agent was introduced into the feed chain, it could have reached cattle.

• After the introduction of the 1997 ban in August 1997, the ability to avoid recycling of BSE-infectivity was somewhat improved. However, the rendering of ruminant material (including SRM and fallen stock) is inadequate (non pressurized), and cross-contamination potentials of cattle feed with other feeds remain.

• Therefore, the system is still unable to avoid recycling of BSE-infectivity if already present in the system or incoming.

Feeding

Until August 1997, RMBM was legally fed to cattle. Feeding was therefore "not OK". In August 1997 an RMBM-ban was introduced but feeding of non-ruminant MBM to cattle remained legal as well as feeding of RMBM to non-ruminant animals (farm animals and pets). An RMBM ban is difficult to maintain, as only labels can distinguish the various MMBMs. This makes control of the feed ban very difficult because analytical differentiation between ruminant and non-ruminant MBM is difficult if not impossible.

Due to the highly specialised production system in the USA, various mammalian MBM streams can be separated. Such a feed ban would therefore be assessed as "reasonably OK", for all regions where this highly specialised system exists. However, several areas in the USA do have mixed farming and mixed feed mills, and in such regions an RMBM ban would not suffice. Additionally, official controls for cattle feeds to control for compliance with the ban started in 2002. Thus, for the whole country, the assessment of the feeding after 1997 remains "not OK", but improving.

Rendering

The rendering industry is operating with processes that are not known to reduce

infectivity. It is therefore concluded that rendering was and is "not OK".

SRM-removal

SRM were and are still rendered for feed, as are (parts of) the fallen stock. SRMremoval

is therefore regarded as "not OK".

BSE-surveillance

Before 1989, the ability of the system to identify (and eliminate) BSE-cases was

limited. Since 1990 this ability is improved, thanks to a specific (passive) BSE

surveillance. The initiated introduction of active surveillance in risk populations

should improve the system significantly.

On the basis of the available information, it has to be concluded that the country's

BSE/cattle system was extremely unstable until today, i.e., it would have recycled and

amplified BSE-infectivity very fast, should it have entered the system. The stability of

the BSE/cattle system in the USA overtime is as given in table 4.

The present assessment modifies the stability assessment of the previous GBR report

in 2000 mainly due to a different perception of the impact of BSE surveillance on

stability and of the efficiency of the RMBM feed ban.

Interaction of stability and external challenge in the USA

Period Stability External Challenge Internal challenge

1980 to

1985

1986 to

1990

Moderate Possibly present

1991 to 1995

Very high

1996 to

2000

2001 to

2003

Extremely unstable Extremely high Likely to be present and growing

5. CONCLUSION ON THE GEOGRAPHICAL BSE-RISK

5.1 The current GBR as function of the past stability and challenge

• The current geographical BSE risk (GBR) level is III, i.e. it is likely but not

confirmed that domestic cattle are (clinically or pre-clinically) infected with the

BSE-agent.

Note1: It is also worth noting that the current GBR conclusions are not dependent on

the large exchange of imports between USA and Canada. External challenge due to

exports to the USA from European countries varied from moderate to high. These

challenges indicate that it was likely that BSE infectivity was introduced into the

North American continent.

snip...please see full text ;

http://www.efsa.europa.eu/en/scdocs/doc/3rax1.pdf






UK EXPORTS OF LIVE CATTLE BY VALUE 1986-96


http://web.archive.org/web/20060517075059/http://www.bseinquiry.gov.uk/files/mb/m11f/tab11.pdf





U.K. EXPORTS OF MEAL OF MEAT AND MEAT OFFAL; GREAVES ;


http://web.archive.org/web/20060517075122/http://www.bseinquiry.gov.uk/files/mb/m12/tab12.pdf






HOWEVER, my files show 44 tons of greaves for USA. ...TSS



Subject: Re: exports from the U.K. of it's MBM to U.S.???

From: S.J.Pearsall@esg.maff.gsi.gov.uk

Date: Tue, 8 Feb 2000 14:03:16 +0000

To: flounder@wt.net (Receipt Notification Requested) (Non Receipt Notification Requested)

Terry Meat and bonemeal is not specifically classified for overseas trade purposes. The nearest equivalent is listed as flours and meals of meat or offals (including tankage), unfit for human consumption; greaves.

UK exports of this to the US are listed below:

Country Tonnes

1980

1981 12

1982

1983

1984 10

1985 2

1986

1987

1988

1989 20

1990

Data for exports between 1975 and 1979 are not readily available. These can be obtained (at a charge) from data retailers appointed by HM Customs and Excise: BTSL (Tel: 01372 463121) or Abacus (01245 252222).

Best wishes Simon Pearsall

Overseas trade statistics Stats (C&F)C

====================================== END...TSS




BANNED SUSPECT MAD COW FEED IN COMMERCE 2006-2007, SOME 10 YEARS AFTER THE INFAMOUS PARTIAL AND VOLUNTARY MAD COW FEED BAN or August 4, 1997, that was nothing more than ink on paper, so really, there was no BSE triple fire wall at all, and this was improving ???

*** BANNED MAD COW FEED IN THE USA IN COMMERCE TONS AND TONS

THIS is just ONE month report, of TWO recalls of prohibited banned MBM, which is illegal, mixed with 85% blood meal, which is still legal, but yet we know the TSE/BSE agent will transmit blood. we have this l-BSE in North America that is much more virulent and there is much concern with blood issue and l-BSE as there is with nvCJD in humans. some are even starting to be concerned with sporadic CJD and blood, and there are studies showing transmission there as well. ... this is one month recall page, where 10 MILLION POUNDS OF BANNED MAD COW FEED WENT OUT INTO COMMERCE, TO BE FED OUT. very little of the product that reaches commerce is ever returned via recall, very, very little. this was 2007, TEN YEARS AFTER THE AUGUST 4, 1997, PARTIAL AND VOLUNTARY MAD COW FEED BAN IN THE USA, that was nothing but ink on paper. i have listed the tonnage of mad cow feed that was in ALABAMA in one of the links too, this is where the infamous g-h-BSEalabama case was, a genetic relation matching the new sporadic CJD in the USA. seems this saga just keeps getting better and better.......$$$

10,000,000+ LBS. of PROHIBITED BANNED MAD COW FEED I.E. BLOOD LACED MBM IN COMMERCE USA 2007

Date: March 21, 2007 at 2:27 pm PST

RECALLS AND FIELD CORRECTIONS: VETERINARY MEDICINES -- CLASS II

___________________________________

PRODUCT

Bulk cattle feed made with recalled Darling's 85% Blood Meal, Flash Dried, Recall # V-024-2007

CODE

Cattle feed delivered between 01/12/2007 and 01/26/2007

RECALLING FIRM/MANUFACTURER

Pfeiffer, Arno, Inc, Greenbush, WI. by conversation on February 5, 2007.

Firm initiated recall is ongoing.

REASON

Blood meal used to make cattle feed was recalled because it was cross- contaminated with prohibited bovine meat and bone meal that had been manufactured on common equipment and labeling did not bear cautionary BSE statement.

VOLUME OF PRODUCT IN COMMERCE

42,090 lbs.

DISTRIBUTION

WI

___________________________________

PRODUCT

Custom dairy premix products: MNM ALL PURPOSE Pellet, HILLSIDE/CDL Prot- Buffer Meal, LEE, M.-CLOSE UP PX Pellet, HIGH DESERT/ GHC LACT Meal, TATARKA, M CUST PROT Meal, SUNRIDGE/CDL PROTEIN Blend, LOURENZO, K PVM DAIRY Meal, DOUBLE B DAIRY/GHC LAC Mineral, WEST PIONT/GHC CLOSEUP Mineral, WEST POINT/GHC LACT Meal, JENKS, J/COMPASS PROTEIN Meal, COPPINI - 8# SPECIAL DAIRY Mix, GULICK, L-LACT Meal (Bulk), TRIPLE J - PROTEIN/LACTATION, ROCK CREEK/GHC MILK Mineral, BETTENCOURT/GHC S.SIDE MK-MN, BETTENCOURT #1/GHC MILK MINR, V&C DAIRY/GHC LACT Meal, VEENSTRA, F/GHC LACT Meal, SMUTNY, A- BYPASS ML W/SMARTA, Recall # V-025-2007

CODE

The firm does not utilize a code - only shipping documentation with commodity and weights identified.

RECALLING FIRM/MANUFACTURER

Rangen, Inc, Buhl, ID, by letters on February 13 and 14, 2007. Firm initiated recall is complete.

REASON

Products manufactured from bulk feed containing blood meal that was cross contaminated with prohibited meat and bone meal and the labeling did not bear cautionary BSE statement.

VOLUME OF PRODUCT IN COMMERCE

9,997,976 lbs.

DISTRIBUTION

ID and NV

END OF ENFORCEMENT REPORT FOR MARCH 21, 2007

http://www.fda.gov/Safety/Recalls/EnforcementReports/2007/ucm120446.htm



see Alabama banned suspect mad cow feed in commerce ;

Saturday, August 14, 2010

BSE Case Associated with Prion Protein Gene Mutation (g-h-BSEalabama) and VPSPr PRIONPATHY

*** (see mad cow feed in COMMERCE IN ALABAMA...TSS)

BANNED MAD COW FEED IN COMMERCE IN ALABAMA

Date: September 6, 2006 at 7:58 am PST PRODUCT

a) EVSRC Custom dairy feed, Recall # V-130-6;

b) Performance Chick Starter, Recall # V-131-6;

c) Performance Quail Grower, Recall # V-132-6;

d) Performance Pheasant Finisher, Recall # V-133-6.

CODE None RECALLING FIRM/MANUFACTURER Donaldson & Hasenbein/dba J&R Feed Service, Inc., Cullman, AL, by telephone on June 23, 2006 and by letter dated July 19, 2006. Firm initiated recall is complete.

REASON

Dairy and poultry feeds were possibly contaminated with ruminant based protein.

VOLUME OF PRODUCT IN COMMERCE 477.72 tons

DISTRIBUTION AL

______________________________

http://www.fda.gov/bbs/topics/enforce/2006/ENF00968.html

PRODUCT Bulk custom dairy pre-mixes,

Recall # V-120-6 CODE None RECALLING FIRM/MANUFACTURER Ware Milling Inc., Houston, MS, by telephone on June 23, 2006. Firm initiated recall is complete. REASON Possible contamination of dairy animal feeds with ruminant derived meat and bone meal.

VOLUME OF PRODUCT IN COMMERCE 350 tons

DISTRIBUTION AL and MS

______________________________

PRODUCT

a) Tucker Milling, LLC Tm 32% Sinking Fish Grower, #2680-Pellet, 50 lb. bags, Recall # V-121-6;

b) Tucker Milling, LLC #31120, Game Bird Breeder Pellet, 50 lb. bags, Recall # V-122-6;

c) Tucker Milling, LLC #31232 Game Bird Grower, 50 lb. bags, Recall # V-123-6;

d) Tucker Milling, LLC 31227-Crumble, Game Bird Starter, BMD Medicated, 50 lb bags, Recall # V-124-6;

e) Tucker Milling, LLC #31120, Game Bird Breeder, 50 lb bags, Recall # V-125-6;

f) Tucker Milling, LLC #30230, 30 % Turkey Starter, 50 lb bags, Recall # V-126-6;

g) Tucker Milling, LLC #30116, TM Broiler Finisher, 50 lb bags, Recall # V-127-6

CODE All products manufactured from 02/01/2005 until 06/20/2006 RECALLING FIRM/MANUFACTURER Recalling Firm: Tucker Milling LLC, Guntersville, AL, by telephone and visit on June 20, 2006, and by letter on June 23, 2006. Manufacturer: H. J. Baker and Brothers Inc., Stamford, CT. Firm initiated recall is ongoing.

REASON Poultry and fish feeds which were possibly contaminated with ruminant based protein were not labeled as "Do not feed to ruminants".

VOLUME OF PRODUCT IN COMMERCE 7,541-50 lb bags

DISTRIBUTION AL, GA, MS, and TN

END OF ENFORCEMENT REPORT FOR AUGUST 9, 2006

###

http://www.fda.gov/bbs/topics/ENFORCE/2006/ENF00964.html

Subject: MAD COW FEED RECALL AL AND FL VOLUME OF PRODUCT IN COMMERCE 125 TONS Products manufactured from 02/01/2005 until 06/06/2006

Date: August 6, 2006 at 6:16 pm PST PRODUCT

a) CO-OP 32% Sinking Catfish, Recall # V-100-6;

b) Performance Sheep Pell W/Decox/A/N, medicated, net wt. 50 lbs, Recall # V-101-6;

c) Pro 40% Swine Conc Meal -- 50 lb, Recall # V-102-6;

d) CO-OP 32% Sinking Catfish Food Medicated, Recall # V-103-6;

e) "Big Jim's" BBB Deer Ration, Big Buck Blend, Recall # V-104-6;

f) CO-OP 40% Hog Supplement Medicated Pelleted, Tylosin 100 grams/ton, 50 lb. bag, Recall # V-105-6;

g) Pig Starter Pell II, 18% W/MCDX Medicated 282020, Carbadox -- 0.0055%, Recall # V-106-6;

h) CO-OP STARTER-GROWER CRUMBLES, Complete Feed for Chickens from Hatch to 20 Weeks, Medicated, Bacitracin Methylene Disalicylate, 25 and 50 Lbs, Recall # V-107-6;

i) CO-OP LAYING PELLETS, Complete Feed for Laying Chickens, Recall # 108-6;

j) CO-OP LAYING CRUMBLES, Recall # V-109-6;

k) CO-OP QUAIL FLIGHT CONDITIONER MEDICATED, net wt 50 Lbs, Recall # V-110-6;

l) CO-OP QUAIL STARTER MEDICATED, Net Wt. 50 Lbs, Recall # V-111-6;

m) CO-OP QUAIL GROWER MEDICATED, 50 Lbs, Recall # V-112-6 CODE

Product manufactured from 02/01/2005 until 06/06/2006

RECALLING FIRM/MANUFACTURER Alabama Farmers Cooperative, Inc., Decatur, AL, by telephone, fax, email and visit on June 9, 2006. FDA initiated recall is complete.

REASON Animal and fish feeds which were possibly contaminated with ruminant based protein not labeled as "Do not feed to ruminants".

VOLUME OF PRODUCT IN COMMERCE 125 tons

DISTRIBUTION AL and FL

END OF ENFORCEMENT REPORT FOR AUGUST 2, 2006

###

http://www.fda.gov/bbs/topics/enforce/2006/ENF00963.html

MAD COW FEED RECALL USA EQUALS 10,878.06 TONS NATIONWIDE

Sun Jul 16, 2006 09:22 71.248.128.67

RECALLS AND FIELD CORRECTIONS: VETERINARY MEDICINE -- CLASS II

______________________________

PRODUCT

a) PRO-LAK, bulk weight, Protein Concentrate for Lactating Dairy Animals, Recall # V-079-6;

b) ProAmino II, FOR PREFRESH AND LACTATING COWS, net weight 50lb (22.6 kg), Recall # V-080-6;

c) PRO-PAK, MARINE & ANIMAL PROTEIN CONCENTRATE FOR USE IN ANIMAL FEED, Recall # V-081-6;

d) Feather Meal, Recall # V-082-6 CODE

a) Bulk

b) None

c) Bulk

d) Bulk

RECALLING FIRM/MANUFACTURER H. J. Baker & Bro., Inc., Albertville, AL, by telephone on June 15, 2006 and by press release on June 16, 2006. Firm initiated recall is ongoing.

REASON

Possible contamination of animal feeds with ruminent derived meat and bone meal.

VOLUME OF PRODUCT IN COMMERCE 10,878.06 tons

DISTRIBUTION Nationwide

END OF ENFORCEMENT REPORT FOR July 12, 2006

###

http://www.fda.gov/bbs/topics/enforce/2006/ENF00960.html


Saturday, November 6, 2010

TAFS1 Position Paper on Position Paper on Relaxation of the Feed Ban in the EU Berne, 2010 TAFS

INTERNATIONAL FORUM FOR TRANSMISSIBLE ANIMAL DISEASES AND FOOD SAFETY a non-profit Swiss Foundation

http://madcowfeed.blogspot.com/2010/11/tafs1-position-paper-on-position-paper.html




Archive Number 20101206.4364 Published Date 06-DEC-2010 Subject PRO/AH/EDR> Prion disease update 2010 (11)

PRION DISEASE UPDATE 2010 (11)

http://www.promedmail.org/pls/apex/f?p=2400:1001:5492868805159684::NO::F2400_P1001_BACK_PAGE,F2400_P1001_PUB_MAIL_ID:1000,86129




NOW, what about that mad cow feed from atypical BSE in commerce and SRM regulations ???




Research Project: Study of Atypical Bse Location: Virus and Prion Research Unit

Project Number: 3625-32000-086-05 Project Type: Specific Cooperative Agreement

Start Date: Sep 15, 2004 End Date: Sep 14, 2009

Objective: The objective of this cooperative research project with Dr. Maria Caramelli from the Italian BSE Reference Laboratory in Turin, Italy, is to conduct comparative studies with the U.S. bovine spongiform encephalopathy (BSE) isolate and the atypical BSE isolates identified in Italy. The studies will cover the following areas: 1. Evaluation of present diagnostics tools used in the U.S. for the detection of atypical BSE cases. 2. Molecular comparison of the U.S. BSE isolate and other typical BSE isolates with atypical BSE cases. 3. Studies on transmissibility and tissue distribution of atypical BSE isolates in cattle and other species.

Approach: This project will be done as a Specific Cooperative Agreement with the Italian BSE Reference Laboratory, Istituto Zooprofilattico Sperimentale del Piemonte, in Turin, Italy. It is essential for the U.S. BSE surveillance program to analyze the effectiveness of the U.S diagnostic tools for detection of atypical cases of BSE. Molecular comparisons of the U.S. BSE isolate with atypical BSE isolates will provide further characterization of the U.S. BSE isolate. Transmission studies are already underway using brain homogenates from atypical BSE cases into mice, cattle and sheep. It will be critical to see whether the atypical BSE isolates behave similarly to typical BSE isolates in terms of transmissibility and disease pathogenesis. If transmission occurs, tissue distribution comparisons will be made between cattle infected with the atypical BSE isolate and the U.S. BSE isolate. Differences in tissue distribution could require new regulations regarding specific risk material (SRM) removal.

http://www.ushrl.saa.ars.usda.gov/research/projects/projects.htm?accn_no=408490




Saturday, June 12, 2010

PUBLICATION REQUEST AND FOIA REQUEST Project Number: 3625-32000-086-05 Study of Atypical Bse

http://bse-atypical.blogspot.com/2010/06/publication-request-and-foia-request.html



Wednesday, July 28, 2010

re-Freedom of Information Act Project Number 3625-32000-086-05, Study of Atypical BSE UPDATE July 28, 2010

http://bse-atypical.blogspot.com/2010/07/re-freedom-of-information-act-project.html




Friday, October 8, 2010

Scientific reasons for a feed ban of meat-and-bone meal, applicable to all farmed animals including cattle, pigs, poultry, farmed fish and pet food

http://madcowfeed.blogspot.com/2010/10/scientific-reasons-for-feed-ban-of-meat.html




P.9.21

Molecular characterization of BSE in Canada

Jianmin Yang1, Sandor Dudas2, Catherine Graham2, Markus Czub3, Tim McAllister1, Stefanie Czub1 1Agriculture and Agri-Food Canada Research Centre, Canada; 2National and OIE BSE Reference Laboratory, Canada; 3University of Calgary, Canada

Background: Three BSE types (classical and two atypical) have been identified on the basis of molecular characteristics of the misfolded protein associated with the disease. To date, each of these three types have been detected in Canadian cattle.

Objectives: This study was conducted to further characterize the 16 Canadian BSE cases based on the biochemical properties of there associated PrPres. Methods: Immuno-reactivity, molecular weight, glycoform profiles and relative proteinase K sensitivity of the PrPres from each of the 16 confirmed Canadian BSE cases was determined using modified Western blot analysis.

Results: Fourteen of the 16 Canadian BSE cases were C type, 1 was H type and 1 was L type. The Canadian H and L-type BSE cases exhibited size shifts and changes in glycosylation similar to other atypical BSE cases. PK digestion under mild and stringent conditions revealed a reduced protease resistance of the atypical cases compared to the C-type cases. N terminal- specific antibodies bound to PrPres from H type but not from C or L type. The C-terminal-specific antibodies resulted in a shift in the glycoform profile and detected a fourth band in the Canadian H-type BSE.

Discussion: The C, L and H type BSE cases in Canada exhibit molecular characteristics similar to those described for classical and atypical BSE cases from Europe and Japan. This supports the theory that the importation of BSE contaminated feedstuff is the source of C-type BSE in Canada.


*** It also suggests a similar cause or source for atypical BSE in these countries.


http://www.prion2009.com/sites/default/files/Prion2009_Book_of_Abstracts.pdf




let's take a closer look at this new prionpathy or prionopathy, and then let's look at the g-h-BSEalabama mad cow.

This new prionopathy in humans? the genetic makeup is IDENTICAL to the g-h-BSEalabama mad cow, the only _documented_ mad cow in the world to date like this, ......wait, it get's better. this new prionpathy is killing young and old humans, with LONG DURATION from onset of symptoms to death, and the symptoms are very similar to nvCJD victims, OH, and the plaques are very similar in some cases too, bbbut, it's not related to the g-h-BSEalabama cow, WAIT NOW, it gets even better, the new human prionpathy that they claim is a genetic TSE, has no relation to any gene mutation in that family. daaa, ya think it could be related to that mad cow with the same genetic make-up ??? there were literally tons and tons of banned mad cow protein in Alabama in commerce, and none of it transmitted to cows, and the cows to humans there from ??? r i g h t $$$

ALABAMA MAD COW g-h-BSEalabama

In this study, we identified a novel mutation in the bovine prion protein gene (Prnp), called E211K, of a confirmed BSE positive cow from Alabama, United States of America. This mutation is identical to the E200K pathogenic mutation found in humans with a genetic form of CJD. This finding represents the first report of a confirmed case of BSE with a potential pathogenic mutation within the bovine Prnp gene. We hypothesize that the bovine Prnp E211K mutation most likely has caused BSE in "the approximately 10-year-old cow" carrying the E221K mutation.

http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1000156




http://www.plospathogens.org/article/fetchObjectAttachment.action?uri=info%3Adoi%2F10.1371%2Fjournal.ppat.1000156&representation=PDF



Saturday, August 14, 2010

BSE Case Associated with Prion Protein Gene Mutation (g-h-BSEalabama) and VPSPr PRIONPATHY

(see mad cow feed in COMMERCE IN ALABAMA...TSS)

http://prionpathy.blogspot.com/2010/08/bse-case-associated-with-prion-protein.html




Thursday, June 23, 2011

Experimental H-type bovine spongiform encephalopathy characterized by plaques and glial- and stellate-type prion protein deposits

http://transmissiblespongiformencephalopathy.blogspot.com/2011/06/experimental-h-type-bovine-spongiform.html



Saturday, June 25, 2011

Transmissibility of BSE-L and Cattle-Adapted TME Prion Strain to Cynomolgus Macaque


"BSE-L in North America may have existed for decades"


http://transmissiblespongiformencephalopathy.blogspot.com/2011/06/transmissibility-of-bse-l-and-cattle.html




Sunday, June 26, 2011

Risk Analysis of Low-Dose Prion Exposures in Cynomolgus Macaque


http://transmissiblespongiformencephalopathy.blogspot.com/2011/06/risk-analysis-of-low-dose-prion.html




Wednesday, June 15, 2011

Galveston, Texas - Isle port moves through thousands of heifers headed to Russia, none from Texas, Alabama, or Washington, due to BSE risk factor

http://transmissiblespongiformencephalopathy.blogspot.com/2011/06/galveston-texas-isle-port-moves-through.html



Monday, June 20, 2011 2011

Annual Conference of the National Institute for Animal Agriculture ATYPICAL NOR-98 LIKE SCRAPIE UPDATE USA

http://nor-98.blogspot.com/2011/06/2011-annual-conference-of-national.html




Monday, June 27, 2011

Comparison of Sheep Nor98 with Human Variably Protease-Sensitive Prionopathy and Gerstmann-Sträussler-Scheinker Disease

http://prionopathy.blogspot.com/2011/06/comparison-of-sheep-nor98-with-human.html




Monday, June 27, 2011

Zoonotic Potential of CWD: Experimental Transmissions to Non-Human Primates

http://chronic-wasting-disease.blogspot.com/2011/06/zoonotic-potential-of-cwd-experimental.html




Sunday, July 03, 2011

Prion Disease Detection, PMCA Kinetics, and IgG in Urine from Naturally/Experimentally Infected Scrapie Sheep and Preclinical/Clinical CWD Deer

http://chronic-wasting-disease.blogspot.com/2011/07/prion-disease-detection-pmca-kinetics.html




Saturday, June 18, 2011

Self-propagation and transmission of misfolded mutant SOD1 Prion or Prion-like phenomenon?

http://transmissiblespongiformencephalopathy.blogspot.com/2011/06/self-propagation-and-transmission-of.html




Wednesday, June 29, 2011

TSEAC Meeting August 1, 2011 donor deferral

http://tseac.blogspot.com/2011/06/tseac-meeting-august-1-2011-donor.html




Thursday, May 26, 2011

Travel History, Hunting, and Venison Consumption Related to Prion Disease Exposure, 2006-2007 FoodNet Population Survey

Journal of the American Dietetic Association Volume 111, Issue 6 , Pages 858-863, June 2011.

http://transmissiblespongiformencephalopathy.blogspot.com/2011/05/travel-history-hunting-and-venison.html




Monday, May 23, 2011

Atypical Prion Diseases in Humans and Animals 2011

Top Curr Chem (2011)

DOI: 10.1007/128_2011_161

# Springer-Verlag Berlin Heidelberg 2011

Michael A. Tranulis, Sylvie L. Benestad, Thierry Baron, and Hans Kretzschmar

http://bse-atypical.blogspot.com/2011/05/atypical-prion-diseases-in-humans-and.html




Saturday, March 5, 2011

MAD COW ATYPICAL CJD PRION TSE CASES WITH CLASSIFICATIONS PENDING ON THE RISE IN NORTH AMERICA

http://transmissiblespongiformencephalopathy.blogspot.com/2011/03/mad-cow-atypical-cjd-prion-tse-cases.html




Tuesday, April 26, 2011

sporadic CJD RISING Text and figures of the latest annual report of the NCJDRSU covering the period 1990-2009 (published 11th March 2011)

http://creutzfeldt-jakob-disease.blogspot.com/2011/04/sporadic-cjd-rising-text-and-figures-of.html




Monday, November 23, 2009

BSE GBR RISK ASSESSMENTS UPDATE NOVEMBER 23, 2009 COMMISSION OF THE EUROPEAN COMMUNITIES AND O.I.E. COMMISSION DECISION of 11 November 2009

http://docket-aphis-2006-0041.blogspot.com/2009/11/bse-gbr-risk-assessments-update.html




----- Original Message -----

From: Terry S. Singeltary Sr.

To: Debra.Beasley@aphis.usda.gov

Sent: Tuesday, November 24, 2009 11:01 AM

Subject: OIE has recently published its proposed animal welfare guidelines for public comment

Greetings USDA/APHIS et al,

I would kindly like to comment on OIE proposed guidelines.

AS I said before, OIE should hang up there jock strap now, since it appears they will buckle every time a country makes some political hay about trade protocol, commodities and futures. IF they are not going to be science based, they should do everyone a favor and dissolve there organization. THE reason most every country around the globe came down with BSE/TSE in their cattle, were due to the failed and flawed BSE/TSE testing and surveillance policy of the O.I.E. NOW, they don't even acknowledge atypical scrapie it seems, as one for concern $


Monday, November 23, 2009

BSE GBR RISK ASSESSMENTS UPDATE NOVEMBER 23, 2009 COMMISSION OF THE EUROPEAN COMMUNITIES AND O.I.E.

http://docket-aphis-2006-0041.blogspot.com/2009/11/bse-gbr-risk-assessments-update.html




Tuesday, May 24, 2011 2:24 PM

O.I.E. Terrestrial Animal Health Standards Commission and prion (TSE) disease reporting 2011

http://transmissiblespongiformencephalopathy.blogspot.com/2011/05/oie-terrestrial-animal-health-standards.html




Sunday, June 5, 2011

PRION TSE FUNDING, WHAT ARE THE PRIORITIES of APHCA, ASEAN, OIE, Korea, and USA ?

http://transmissiblespongiformencephalopathy.blogspot.com/2011/06/prion-tse-funding-what-are-priorities.html




Docket APHIS-2006-0041 Docket Title Bovine Spongiform Encephalopathy; Minimal-Risk Regions; Importation of Live Bovines and Products Derived from Bovines Commodities Docket Type Rulemaking Document APHIS-2006-0041-0001 Document Title Bovine Spongiform Encephalopathy; Minimal-Risk Regions; Importation of Live Bovines and Products Derived From Bovines Public Submission APHIS-2006-0041-0006 Public Submission Title Comment from Terry S Singletary Sr Views Add Comments How To Comment

snip...

MY personal belief, since you ask, is that not only the Canadian border, but the USA border, and the Mexican border should be sealed up tighter than a drum for exporting there TSE tainted products, until a validated, 100% sensitive test is available, and all animals for human and animal consumption are tested. all we are doing is the exact same thing the UK did with there mad cow poisoning when they exported it all over the globe, all the while knowing what they were doing. this BSE MRR policy is nothing more than a legal tool to do just exactly what the UK did, thanks to the OIE and GW, it's legal now. and they executed Saddam for poisoning ???

go figure....

Terry S. Singeltary Sr. P.O. Box 42 Bacliff, Texas USA 77518

http://www.regulations.gov/fdmspublic/component/main?main=DocumentDetail&d=APHIS-2006-0041-0006





I IMPLORE, that due to the lack of surveillance and proper BSE/TSE protocols for testing and surveillance, the fact that sporadic CJD in the USA has tripled over the last few years or so, the new findings of BASE, the fact that CWD and Scrapie are out of control in the USA, I IMPLORE that the BSE MRR policy be repealed and the BSE GBR risk assessments revised to address all TSEs i.e. TSE GBR, for the following reasons ; ----- Original Message ----- From: "Terry S. Singeltary Sr." To: "EFSA Press" Sent: Tuesday, November 21, 2006 12:21 PM Subject: Re: re-Geographical BSE Risk: EFSA consults on revision of assessment methodology Greetings EFSA, a sad day. i think any weakening of the BSE GBR risk assessments, especially for USA, is a huge mistake. i think the BSE GBR should be revised to include all TSE i.e. TSE GBR.


snip...


your only fooling yourselves with this stupid ukbsenvcjd only theory, and the BSE methology of the OIE. most any coutnry that went by those same OIE BSE guidelines all went down with BSE. THE OIE has now shown they are nothing more than a National Trading Brokerage for all strains of animal TSE. AS i said before, OIE should hang up there jock strap now, since it appears they will buckle every time a country makes some political hay about trade protocol, commodities and futures. IF they are not going to be science based, they should do everyone a favor and dissolve there organization. ...


http://www.fsis.usda.gov/OPPDE/Comments/2006-0011/2006-0011-1.pdf




Terry S. Singeltary SR. P.O. Box 42 Bacliff, Texas USA 77518


http://www.regulations.gov/#!documentDetail;D=APHIS-2006-0026-0012;oldLink=false





Docket APHIS-2006-0041 Docket Title Bovine Spongiform Encephalopathy; Minimal-Risk Regions; Importation of Live Bovines and Products Derived from Bovines Commodities Docket Type Rulemaking Document APHIS-2006-0041-0001 Document Title Bovine Spongiform Encephalopathy; Minimal-Risk Regions; Importation of Live Bovines and Products Derived From Bovines Public Submission APHIS-2006-0041-0028.1 Public Submission Title Attachment to Singletary comment

January 28, 2007

Greetings APHIS,

I would kindly like to submit the following to ;

BSE; MRR; IMPORTATION OF LIVE BOVINES AND PRODUCTS DERIVED FROM BOVINES [Docket No. APHIS-2006-0041] RIN 0579-AC01



http://www.regulations.gov/fdmspublic/ContentViewer?objectId=09000064801f8152&disposition=attachment&contentType=msw8






layperson...tss



Terry S. Singeltary Sr.
P.O. Box 42
Bacliff, Texas USA 77518
flounder9@verizon.net

Tuesday, February 8, 2011

Scientific Opinion on the capacity of oleochemical processes to minimise possible risks linked to TSE in Category 1 animal by-products EFSA

Scientific Opinion on the capacity of oleochemical processes to minimise possible risks linked to TSE in Category 1 animal by-products


EFSA Journal

2011;9(2):1976 [26 pp.]. doi:10.2903/j.efsa.2011.1976

EFSA Panel on Biological Hazards (BIOHAZ)

Panel Members Olivier Andreoletti, Herbert Budka, Sava Buncic, John D. Collins, John Griffin, Arie Havelaar, James Hope, Günter Klein, Tine Hald, James McLauchlin, Christine Mueller-Graf, Christophe Nguyen-Thé, Birgit Noerrung, Miguel Prieto Maradona, Luisa Peixe, Antonia Ricci, John Sofos, John Threlfall, Ivar Vågsholm and Emmanuel Vanopdenbosch.

Acknowledgment

The Panel wishes to thank the members of the Working Group on the capacity of oleochemical processes to minimise possible risks linked to TSE in Category 1 animal by-products: Emmanuel Vanopdenbosch, Christophe Nguyen-The, John Griffin, James Hope and Reinhard Boehm for the preparatory work on this scientific opinion and EFSA staff: Alessandro Broglia for the support provided to this scientific opinion. Contact biohaz@efsa.europa.eu Type:

Opinion of the Scientific Committee/Scientific Panel On request from: European Commission Question number: EFSA-Q-2010-00969

Adopted: 20 January 2011 Published: 07 February 2011 Affiliation: European Food Safety Authority (EFSA), Parma, Italy Article Full article (0.2 Mb) send print cite

Abstract

The capacity of specific oleochemical processes including several steps (i.e. bleaching, fat splitting, hydrogenation, concentration, distillation and refinement) in order to minimise possible risks linked to TSE infectivity in tallow including Category 1 animal by-products (ABP) was assessed. Under the new ABP Regulation (Reg. EC No 1069/2009), the use of Category 1 tallow for oleochemical products may be also authorised, if the processes are proved to be capable of sufficiently inactivating any potential risks linked to TSEs. The processes considered in this opinion are based on different treatment steps in different combination, but with respect to infectivity reduction the major contribution derives from hydrolytic fat splitting and hydrogenation, so to obtain fatty acids and glycerol. It is concluded that if the parameters are fully met as declared by the applicant, certain processes can be considered effective in significantly reducing the TSE infectivity in the end products using Category 1 tallow. However, considering the uncertainties on the TSE infectivity reduction in oleochemical products derived from Cat. 1 material, these products cannot be reliably regarded to be free of infectivity and therefore could pose a risk if they entered the food and feed chain.

http://www.efsa.europa.eu/en/efsajournal/pub/1976.htm?WT.mc_id=EFSAHL01&emt=1


Summary (0.1 Mb) Following a request from the European Commission, the EFSA Scientific Panel on Biological Hazards (BIOHAZ) was asked to provide scientific advice on the capacity of a specific oleochemical processes to minimise possible risks linked to TSE infectivity in tallow including category 1 material.

The current Regulation (EC) No 1774/2002 on animal by-products foresees that rendered fats obtained from Category 2 and Category 3 materials may be used for the manufacture of oleochemical products.

Under the new ABP Regulation (Reg. EC No 1069/2009), the use of Category 1 material in the production of oleochemical products may be also authorised, provided that the manufacturing processes which are applied by the oleochemical industry are capable of sufficiently inactivating any potential risks linked to TSE. This would allow the use of such products in various applications, such as in soaps, cosmetic products and plastics, regardless of the category of animal by-products that are used as starting materials.

The European Oleochemicals and Allied Products Group (APAG), a sector group of the European Chemical Industry Council (Cefic), has submitted scientific evidence to the Commission regarding the capacity of oleochemical processes to inactivate possible risks linked to transmissible spongiform encephalopathies (TSEs) in animal by-products not intended for human consumption (ABPs).

The oleochemical processes considered consist mainly of hydrolytic fat splitting of tallow to obtain fatty acids and glycerol, under the conditions of 200°C, 16 bar of pressure for 20 minutes. The processes can be carried out in a unitower or multitower plant. If saturated fatty acids or hydrogenated tallow are to be obtained, hydrogenation under conditions of 160°C, 12 bar of H2 pressure for 20 minutes is applied in batch or continuous reactors. Eight different processes, consisting of a combination of different steps, can be used according to the different end products and type of reactors used.

The parameters considered are mainly temperature, time and pressure. In the opinion the reduction effects of the different steps that characterise the processes are assessed and, when possible, quantified. The two steps with experimental evidence that contribute to the TSE risk reduction are the hydrolytic fat splitting and the hydrogenation.

It is concluded that if the critical limits of the specific method considered are met, the reduction of TSE infectivity of certain processes is significant. However, considering the uncertainties on the TSE infectivity reduction in oleochemical products derived from Cat. 1 material, these products cannot be reliably regarded to be free of infectivity and therefore could pose a risk if they entered the food and feed chain.

As for efficacy of hydrogenation step, only batch processes can be compared to validated experiments, continuous processes could not be considered effective due to the lack of critical data (i.e. minimum retention time). As for the splitting step carried out in continuous reactors, the processing time represents a sufficient safety margin compared to the minimum requirement, and therefore it is considered effective.

http://www.efsa.europa.eu/en/efsajournal/doc/s1976.pdf


Full Text ;

http://www.efsa.europa.eu/en/efsajournal/doc/1976.pdf


Thursday, July 22, 2010

BSE INQUIRY DFA 18 COSMETICS

From: TSS

Subject: Use of Materials Derived From Cattle in Human Food and Cosmetics [Docket No. 2004N-0081] RIN 0910-AF47

Date: April 17, 2008 at 2:41 pm PST


http://bseinquiry.blogspot.com/2010/07/bse-inquiry-dfa-18-cosmetics.html


http://bseinquiry.blogspot.com/




Saturday, January 29, 2011

Atypical L-Type Bovine Spongiform Encephalopathy (L-BSE) Transmission to Cynomolgus Macaques, a Non-Human Primate

Jpn. J. Infect. Dis., 64 (1), 81-84, 2011


http://transmissiblespongiformencephalopathy.blogspot.com/2011/01/atypical-l-type-bovine-spongiform.html





Tuesday, February 8, 2011


U.S.A. 50 STATE BSE MAD COW CONFERENCE CALL Jan. 9, 2001


http://tseac.blogspot.com/2011/02/usa-50-state-bse-mad-cow-conference.html




http://transmissiblespongiformencephalopathy.blogspot.com/




TSS